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Product Description
This MAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80% of all cases; and small cell, which accounts for roughly 20% of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.
W.H.O., 1982, 2nd ed. Am J. Clin. Path. 77, 123-136. | De Leij, L., et al., 1984, Eur. J. Canc. Clin. Oncol. 20, 123-128. | Souhami, R.L., et al., 1987, Lancet ii, 325-326. | De Leij, L., et al., 1987, In: Application of Monoclonal antibodies in tumor pathology (Ruiter DJ et al., eds), Dordrecht: Martinus Nijhoff, pp 191-210. | Berendsen, H.H., de Leij, L., Postmus, P.E., Ter Haar, J.G., Poppema, S. and The, T.H. 1988. Detection of small cell lung cancer metastases in bone marrow aspirates using monoclonal antibody directed against neuroendocrine differentiation antigen. J. Clin. Pathol. 41: 273-276
Additional Information
| Conjugation |
Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP
|
| Size |
50 uL, 100 uL, 250 uL, 500 uL
|
| Supplied As |
Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA
|
| Antibody type |
Primary
|
| Host species |
Mouse
|
| Reactivity (target) |
Small Cell Lung Cancer (SCLC) (MOC-52)
|
| Clonality |
Monoclonal
|
| Isotype |
IgG1, kappa
|
| Clone |
MOC-52
|
| Molecular weight |
145 kDa
|
| Synonyms |
Not Known
|
| Entrez gene ID |
Not Known
|
| SwissProt |
Not Known
|
| Unigene |
Not Known
|
| Immunogen |
Lung Cancer-associated antigen isolated from small cell lung carcinoma-derived cell line
|
| Species reactivity |
Human
|
| Applications |
Immunohistology (frozen), Immunofluorescence
|
| Cellular localization |
Cell surface
|
| Application notes |
Immunocytochemistry Frozen 0.5-1.0 ug/mL for 30 minutes at RT, Immunofluorescence 0.5-1 ug/mL, Optimal dilution for a specific application should be determined by user
|
| Positive control |
Human small cell lung carcinoma, adrenal gland
|
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