Monoclonal anti Small Cell Lung Cancer (SCLC) (MOC 52)

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Catalog #: BNUB0329
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Product Description

This MAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80% of all cases; and small cell, which accounts for roughly 20% of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.

W.H.O., 1982, 2nd ed. Am J. Clin. Path. 77, 123-136. | De Leij, L., et al., 1984, Eur. J. Canc. Clin. Oncol. 20, 123-128. | Souhami, R.L., et al., 1987, Lancet ii, 325-326. | De Leij, L., et al., 1987, In: Application of Monoclonal antibodies in tumor pathology (Ruiter DJ et al., eds), Dordrecht: Martinus Nijhoff, pp 191-210. | Berendsen, H.H., de Leij, L., Postmus, P.E., Ter Haar, J.G., Poppema, S. and The, T.H. 1988. Detection of small cell lung cancer metastases in bone marrow aspirates using monoclonal antibody directed against neuroendocrine differentiation antigen. J. Clin. Pathol. 41: 273-276

Additional Information


Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP


50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type


Host species


Reactivity (target)

Small Cell Lung Cancer (SCLC) (MOC-52)




IgG1, kappa



Molecular weight

145 kDa


Not Known

Entrez gene ID

Not Known


Not Known


Not Known


Lung Cancer-associated antigen isolated from small cell lung carcinoma-derived cell line

Species reactivity



Immunohistology (frozen), Immunofluorescence

Cellular localization

Cell surface

Application notes

Immunocytochemistry Frozen 0.5-1.0 ug/mL for 30 minutes at RT, Immunofluorescence 0.5-1 ug/mL, Optimal dilution for a specific application should be determined by user

Positive control

Human small cell lung carcinoma, adrenal gland

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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