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HLA-DP/-DQ/-DR Recombinant Monoclonal Rabbit Antibody (HLA-DPB1/2967R)

This antibody reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR.

Product Attributes

Antibody number

2967

Reactivity (target)

HLA-DP/-DQ/-DR

Antibody type

Primary

Host species

Rabbit

Clonality

Recombinant Monoclonal

Clone

HLA-DPB1/2967R

Isotype

IgG

Molecular weight

33-35 kDa

Synonyms

HLA-DPB1; HLA-DQA1; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5

Human gene symbol

HLA-DP; HLA-DQ; HLA-DR

Entrez gene ID

3115 (HLA-DP); 3117 (HLA-DQ); 3122 (HLA-DR)

SwissProt

P04440 (HLA-DP); P01908; P01909; P01920 (HLA-DQ); P01903 (HLA-DR)

Unigene

347270 (HLA-DP); 550475 (HLA-DQ); 520048 (HLA-DR)

Immunogen

Non-T, non-B human acute lymphoblastic leukemia REH6 cell line

Cellular localization

Membrane/cell surface

Species reactivity

Human

Applications

Immunohistology (formalin), ELISA

Application notes

ELISA: For coating use Ab at 1-5 ug/mL order Ab without BSA, Immunohistology (formalin): 0.5-1 ug/mL for 30 minutes at RT, Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes

Positive control

Raji cells. Tonsil or lymph node

Shipping condition

Room temperature

Storage Conditions

Store at 2 to 8 °C, Protect fluorescent conjugates from light, Note: store BSA-free antibodies at -10 to -35 °C

Shelf life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Regulatory status

For research use only (RUO)

Research areas

Cancer, Immunology, MHC antigens

Primary Antibody Formats:

  • Conjugates: 100 ug/mL  in PBS 0.1% BSA 0.05% azide
  • HRP conjugates: 100 ug/mL in PBS 0.05% BSA, no azide
  • Purified: 200 ug/mL in PBS 0.05% BSA 0.05% azide
  • Purified, BSA-free: 1 mg/mL in PBS, no BSA, no azide
Conjugation
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Product Description

This antibody reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an  chain (36 kDa) and a  chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six  and ten  chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. See the CF® Dye Brochure for more information. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Stock status: Because Biotium offers a large number of antibody and conjugation options, primary antibody conjugates may be made to order. Typical lead times are up to one week for CF® dye and biotin conjugates, and up to 2-3 weeks for fluorescent protein and enzyme conjugates. Please email order@biotium.com to inquire about stock status and lead times before placing your order.

References

Gatter et al. 1982. J Clin Pathol. 35(11):1253-67.|Gatter et al. 1982. Semin Oncol. 9(4):517-25.

 

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