Monoclonal anti CD1b (100 1A5)

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Catalog #: BNUB1044
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Product Description

The mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin (Workshop IV; Code T015). It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.

Knapp W. et al. (eds) Leukocyte Typing IV, p251-263, Oxford University Press, Oxford, 1989. | Battistini L, et al. CD1b is expressed in multiple sclerosis lesions. J Neuroimmunol 1996, 67(2):145-151. | Khalili-Shirazi A, et al. The distribution of CD1 molecules in inflammatory neuropathy. J Neurol Sci 1998,158(2):154-163. | Maher JK and Kronenberg M. The role of CD1 molecules in immune responses to infection. Curr Opin Immunol 1997, 9(4):456-461Blumberg RS et al. Structure and function of the CD1 family of MHC-like cell surface proteins. Immunol Rev 1995, 147:5-29. | Salamone MC et al. Analysis of CD1 molecules on haematological malignancies of myeloid and lymphoid origin. II. Intracellular detection of CD1 antigens. Dis Markers 1990, 8(5):275-281

Additional Information


Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP


50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type


Host species


Reactivity (target)

CD1b (100-1A5)




IgG2b, kappa



Molecular weight

44 kDa


A1 domain; CD1B; Cortical thymocyte antigen CD1B; hTa1 thymocyte antigen; Ly38; T cell surface glycoprotein CD1b; T6/Leu6

Entrez gene ID







Stimulated human leukocytes

Species reactivity



Flow cytometry, Immunofluorescence

Cellular localization

Cell surface

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1 ug/mL Optimal dilution for a specific application should be determined by user

Positive control

MOLT4 cells. Human thymus.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

Shipment Method: Shipping and handling methods will be assessed and calculated at time of shipment based upon item(s) storage temperature conditions.

Expedited shipment may be requested at time of checkout.

Please note that products with recommended storage at 4°C or -20°C may ship at ambient temperature. This will not affect product performance. When you receive the product, place it under the recommended storage conditions.

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