Monoclonal anti CD4 (EDU 2)

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Catalog #: BNUB0345
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Product Description

Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.This MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.

Reinberz EL et al. eds. Leykcocyte Typing II, Springer-Verlag, Berlin, 1985. | Knapp W. et. al. (eds) Leukocyte Typing IV, p314-330, Oxford University Press, Oxford, 1989.Sattentau QJ, et al. The CD4 antigen: physiological ligand and HIV receptor. Cell. 1988, 52(5):631-633. | Gaubin M, et al. Molecular basis of T lymphocyte CD4 antigen functions. Eur J Clin Chem Clin Biochem. 1996, 34(9):723-728.Mazerolles F, et al. Down regulation of T-cell adhesion by CD4. Hum Immunol. 1991, 31(1):40-6

Additional Information


Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP


50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type


Host species


Reactivity (target)

CD4 (EDU-2)




IgG2a, kappa



Molecular weight

55 kDa


L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell antigen T4/LEU3; T cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Entrez gene ID







Stimulated human leukocytes

Species reactivity

Chimpanzee, Human, Macaca artctoids, Orangutan


Flow cytometry, Immunofluorescence

Cellular localization

Cell surface

Application notes

Does not react with Macaca mulatta (rhesus monkey), others not tested, Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 0.5-1 ug/mL, Optimal dilution for a specific application should be determined by user

Positive control

Human peripheral blood mononuclear cells (PBMCs), CCRF-CEM or HL-60. Lymph node or tonsil.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

Shipment Method: Shipping and handling methods will be assessed and calculated at time of shipment based upon item(s) storage temperature conditions.

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Please note that products with recommended storage at 4°C or -20°C may ship at ambient temperature. This will not affect product performance. When you receive the product, place it under the recommended storage conditions.

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