Monoclonal anti TRP1 (Tyrosinase Related Protein 1) (TA99)

BNUB0806-0
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Product Description

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

FASEB J. 2010;24(5):1616-29. | Clin Cancer Res. 2007;13:566-75. |

Additional Information

Conjugation

Purified with BSA, 0.2 mg/mL, Purified, BSA-free, 1 mg/mL, CF405S, CF405M, CF488A, CF543, CF555, CF568, CF594, CF640R, CF647, CF660R, CF680, CF680R, CF770, Biotin, R-PE, APC, Per-CP, Alkaline Phosphatase, HRP

Size

50 uL, 100 uL, 250 uL, 500 uL

Supplied As

Purified: 0.2 mg/mL in PBS/0.05% BSA/0.05% azide, Purified, BSA-free: 1 mg/mL in PBS without azide, Conjugates: 0.1 mg/mL in PBS/0.1% BSA/0.05% azide, HRP conjugates: 0.1 mg/mL in PBS/0.05% BSA

Antibody type

Primary

Host species

Mouse

Reactivity (target)

TRP1 (Tyrosinase Related Protein 1) (TA99)

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone

TA99

Molecular weight

75 kDa

Synonyms
Entrez gene ID

7306

SwissProt

P17643

Unigene

270279

Immunogen

SK-MEL-23 cells

Species reactivity

Human, Mouse

Applications

Immunohistology (frozen), Flow cytometry, Immunofluorescence

Cellular localization

Cytoplasmic

Application notes

Flow Cytometry (0.5-1 ug/million cells/0.1 mL), Immunofluorescence 1-2 ug/mL, Immunohistology Frozen only 0.5-1 ug/mL for 30 minutes at RT, Optimal dilution for a specific application should be determined by user

Positive control

SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells or Melanoma.

MSDS (PDF):MSDS Primary antibodies

Protocol (PDF): Protocols for antibody-based detection

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