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CD8a Monoclonal Mouse Antibody (SK1) – Biotium Choice

CD8a (clone SK1) is a validated mouse monoclonal antibody that recognizes CD8a, a transmembrane glycoprotein and co-receptor found in T cells. The antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance.

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Product Description

CD8a (clone SK1) is a mouse monoclonal antibody derived from the CD8 alpha chain. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to CF® Dyes and Astral™ tandem dyes. They are supplied in PBS, 0.1% BSA, 0.05% azide.

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

As an isotype control, we recommend Isotype Control, Monoclonal Mouse IgG1 Kappa (IGG1/1331) for this antibody.

Discover Sharper Signals and Unmatched Panel Flexibility with Biotium Choice Antibodies
Powered by CF® Dyes and Astral Leap™ Tandem Dyes

Biotium Choice antibodies are carefully curated and validated in-house to offer exceptional signal-to-noise. Labeled with our advanced CF® Dyes and Astral Leap™ tandem dyes, they are our top-recommended antibodies for flow cytometry and other applications.

Biotium Choice Antibody Features

  • Robust and validated clones against common targets
  • Developed and optimized for flow cytometry and other applications
  • Conjugated to bright, photostable CF® Dyes for superior signal and clarity
  •  Also available with Astral Leap™ tandem dyes for expanding multiplexing
  • New antibody clones and dye conjugates continuously in development

View our full catalog of Biotium Choice antibodies

Identifying Biotium validated antibodies

Biotium scientists validate and optimize select antibodies in our catalog, marked with a check mark next to the product name. This symbol indicates the antibody is highly recommended for the specified application(s).

Look for this symbol next to the product name on product pages and search results

CD8a Monoclonal Mouse Antibody (SK1) - Biotium Choice

ConjugationEx/EmConc.SizeCatalog No.
CF®405S411/431 nm200 ug/mL25 tests (125 uL)P009-405S-125CF®405S Features
100 tests (500 uL)P009-405S-500
CF®405M416/452 nm100 ug/mL25 tests (125 uL)P009-405M-125CF®405M Features
100 tests (500 uL)P009-405M-500
CF®405L413/547 nm300 ug/mL25 tests (125 uL)P009-405L-125CF®405L Features
100 tests (500 uL)P009-405L-500
CF®488A490/516 nm100 ug/mL25 tests (125 uL)P009-488A-125CF®488A Features
100 tests (500 uL)P009-488A-500
CF®503R503/532 nm50 ug/mL25 tests (125 uL)P009-503R-125CF®503R Features
100 tests (500 uL)P009-503R-500
CF®514516/549 nm100 ug/mL25 tests (125 uL)P009-514-125CF®514 Features
100 tests (500 uL)P009-514-500
CF®568562/584 nm100 ug/mL25 tests (125 uL)P009-568-125CF®568 Features
100 tests (500 uL)P009-568-500
CF®575575/601 nm200 ug/mL25 tests (125 uL)P009-575-125
100 tests (500 uL)P009-575-500
RPE-Astral™616496, 546, 566/617 nm200 ug/mL25 tests (125 uL)P009-R616-125
100 tests (500 uL)P009-568-500
CF®647Plus652/668 nm50 ug/mL25 tests (125 uL)P009-647P-125
100 tests (500 uL)P009-647P-500
CF®660C667/685 nm100 ug/mL25 tests (125 uL)P009-660C-125CF®660C Features
100 tests (500 uL)P009-660C-500
CF®700696/721 nm100 ug/mL25 tests (125 uL)P009-700-125CF®700 Features
100 tests (500 uL)P009-700-500
CF®820822/835 nm40 ug/mL25 tests (125 uL)P009-820-125CF®820 Features
100 tests (500 uL)P009-820-500
APC-Astral™813633, 638/813 nm50 ug/mL25 tests (125 uL)P009-A813-125
100 tests (500 uL)P009-A813-500
R-PE496, 546, 565/576 nm60 ug/mL25 tests (125 uL)P009-RPE-125
100 tests (500 uL)P009-RPE-500
APC651/660 nm50 ug/mL25 tests (125 uL)P009-APC-125
100 tests (500 uL)P009-APC-500
 

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