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α-Bungarotoxin

A high affinity inhibitor of the nicotinic acetylcholine receptor in the neuromuscular junction. Blocks acetylcholine activity at the postsynaptic membrane.

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Product Description

A potent neurotoxin that is an inhibitor for the motor endplate acetylcholine receptor (Kd = 1 nM to 1 pM). It binds at the neuromuscular junction with high affinity and is often used to study neuromuscular junctions by blocking cholinergic receptors. Alpha-bungarotoxin may also be used for detection of GABA A receptor subsets in cells (1), or for labeling recombinant proteins that express the alpha-bungarotoxin binding site (BBS) epitope tag (2).

  • A polypeptide snake toxin
  • Blocks and inhibits cholinergic receptors
  • White solid soluble in water

Also see our Fluorescent α-Bungarotoxins and Biotin α-Bungarotoxin which can can be used for labeling of nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections. See our complete selection of α-Bungarotoxins below.

α-Bungarotoxin, CF® Dye and Other Conjugates

ConjugationEx/EmSizeCatalog No.Dye Features
UnconjugatedN/A1 mg00010-1
Biotin-XXN/A0.5 mg00017
CF®405S411/431 nm100 ug00002-100ugCF®405S Features
0.5 mg00002
CF®488A490/516 nm100 ug00005-100ugCF®488A Features
0.5 mg00005
CF®543 543/563 nm100 ug00026-100ugCF®543 Features
0.5 mg00026
CF®555554/568 nm100 ug00018-100ugCF®555 Features
0.5 mg00018
CF®568562/584 nm100 ug00006-100ugCF®568 Features
0.5 mg00006
CF®594593/615 nm100 ug00007-100ugCF®594 Features
0.5 mg00007
CF®633629/650 nm100 ug00009-100ugCF®633 Features
0.5 mg00009
CF®640R642/663 nm100 ug00004-100ugCF®640R Features
0.5 mg00004
CF®680R680/701 nm100 ug00003-100ugCF®680R Features
0.5 mg00003
Fluorescein
(FITC)
498/517 nm0.5 mg00011
10 x 50 ug00013
Tetramethylrhodamine
(TRITC)
552/578 nm0.5 mg00012
10 x 50 ug00014
Sulforhodamine-101
(Texas Red®)
595/613 nm0.5 mg00015
10 x 50 ug00016

 

CF is a registered trademark of Biotium, Inc. Texas Red is a registered trademark of Thermo Fisher Scientific.

References

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  14. Am J of Pathol, 177, 2509 (2010), DOI: 10.2353/ajpath.2010.100243
  15. Cell Tissue Biol, 4, 258, (2010), DOI: 10.1134/S1990519X10030077
  16. Neuroscience, 174, 234, (2009), DOI: 10.1016/j.neuroscience.2010.11.016
  17. J Cell Biol, 150, 1385, (2000), DOI: 10.1083/jcb.150.6.1385
  18. Neuron, 23, 675, (1999), DOI: 10.1016/s0896-6273(01)80027-1
  19. Neuron, 12, 167, (1994), DOI: 10.1016/0896-6273(94)90161-9
  20. J Cell Biol, 125, 661, (1994), DOI: 10.1083/jcb.125.3.661
  21. J Biol Chem, 268, 25108, (1993), PMID: 8227074
  22. Muscle Nerve, 5, 140, (1982), DOI: 10.1002/mus.880050211
  23. PNAS 77, 4823, (1980), DOI: 10.1073/pnas.77.8.4823
  24. Science, 196, 540, (1977), DOI: 10.1126/science.850796
 

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