α-Bungarotoxin
A high affinity inhibitor of the nicotinic acetylcholine receptor in the neuromuscular junction. Blocks acetylcholine activity at the postsynaptic membrane.
Please fill in the inquiry form and we will contact you shortly.
Wishlist updated! View wishlist
Product Description
A potent neurotoxin that is an inhibitor for the motor endplate acetylcholine receptor (Kd = 1 nM to 1 pM). It binds at the neuromuscular junction with high affinity and is often used to study neuromuscular junctions by blocking cholinergic receptors. Alpha-bungarotoxin may also be used for detection of GABA A receptor subsets in cells (1), or for labeling recombinant proteins that express the alpha-bungarotoxin binding site (BBS) epitope tag (2).
- A polypeptide snake toxin
- Blocks and inhibits cholinergic receptors
- White solid soluble in water
Also see our Fluorescent α-Bungarotoxins and Biotin α-Bungarotoxin which can can be used for labeling of nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections. See our complete selection of α-Bungarotoxins below.
α-Bungarotoxin, CF® Dye and Other Conjugates
Conjugation | Ex/Em | Size | Catalog No. | Dye Features |
---|---|---|---|---|
Unconjugated | N/A | 1 mg | 00010-1 | |
Biotin-XX | N/A | 0.5 mg | 00017 | |
CF®405S | 411/431 nm | 100 ug | 00002-100ug | CF®405S Features |
0.5 mg | 00002 | |||
CF®488A | 490/516 nm | 100 ug | 00005-100ug | CF®488A Features |
0.5 mg | 00005 | |||
CF®543 | 543/563 nm | 100 ug | 00026-100ug | CF®543 Features |
0.5 mg | 00026 | |||
CF®555 | 554/568 nm | 100 ug | 00018-100ug | CF®555 Features |
0.5 mg | 00018 | |||
CF®568 | 562/584 nm | 100 ug | 00006-100ug | CF®568 Features |
0.5 mg | 00006 | |||
CF®594 | 593/615 nm | 100 ug | 00007-100ug | CF®594 Features |
0.5 mg | 00007 | |||
CF®633 | 629/650 nm | 100 ug | 00009-100ug | CF®633 Features |
0.5 mg | 00009 | |||
CF®640R | 642/663 nm | 100 ug | 00004-100ug | CF®640R Features |
0.5 mg | 00004 | |||
CF®680R | 680/701 nm | 100 ug | 00003-100ug | CF®680R Features |
0.5 mg | 00003 | |||
Fluorescein (FITC) | 498/517 nm | 0.5 mg | 00011 | |
10 x 50 ug | 00013 | |||
Tetramethylrhodamine (TRITC) | 552/578 nm | 0.5 mg | 00012 | |
10 x 50 ug | 00014 | |||
Sulforhodamine-101 (Texas Red®) | 595/613 nm | 0.5 mg | 00015 | |
10 x 50 ug | 00016 |
References
- PNAS, 103, 13, (2006), DOI: 10.1073/pnas.0600847103
- Meth. Enzymol., 521, (2013), DOI: 10.1016/B978-0-12-391862-8.00006-5
- Sci Adv, 6, 15, (2020), DOI: 10.1126/sciadv.aax8382
- Am J Physiol Cell Physiol, (2020) DOI: 10.1152/ajpcell.00453.2019
- Biochem Biophys Res Commun., 523, 214, (2020), DOI: 10.1016/j.bbrc.2019.12.011
- Front Cell Dev Biol., 8, 15, (2020), DOI: 10.3389/fcell.2020.00015
- Biophysics, 64, 772, (2019), DOI: 10.1134/S0006350919050129
- Cell Physiol Biochem, 53, 701, (2019), DOI: 10.33594/000000166
- Biochemistry (Mosc.), 4, 1085, (2019), DOI: 10.1134/S0006297919090116
- Biomaterials, 225, 119537, (2019), DOI: 10.1016/j.biomaterials.2019.119537
- ACS Chem. Biol., 13, 2568, (2018), DOI: 10.1021/acschembio.8b00513
- Cell Mol Neurobiol, 37, 1443, (2017), DOI: 10.1007/s10571-017-0475-3
- Neuroscience, 174, 234, (2011), DOI: 10.1016/j.neuroscience.2010.11.016
- Am J of Pathol, 177, 2509 (2010), DOI: 10.2353/ajpath.2010.100243
- Cell Tissue Biol, 4, 258, (2010), DOI: 10.1134/S1990519X10030077
- Neuroscience, 174, 234, (2009), DOI: 10.1016/j.neuroscience.2010.11.016
- J Cell Biol, 150, 1385, (2000), DOI: 10.1083/jcb.150.6.1385
- Neuron, 23, 675, (1999), DOI: 10.1016/s0896-6273(01)80027-1
- Neuron, 12, 167, (1994), DOI: 10.1016/0896-6273(94)90161-9
- J Cell Biol, 125, 661, (1994), DOI: 10.1083/jcb.125.3.661
- J Biol Chem, 268, 25108, (1993), PMID: 8227074
- Muscle Nerve, 5, 140, (1982), DOI: 10.1002/mus.880050211
- PNAS 77, 4823, (1980), DOI: 10.1073/pnas.77.8.4823
- Science, 196, 540, (1977), DOI: 10.1126/science.850796